ChemicalBook CAS DataBase List 2630904-45-7

2630904-45-7

Name	MRTX-1719
CAS	2630904-45-7
Molecular Formula	C23H18ClFN6O2
Molecular Weight	464.89
MOL File	2630904-45-7.mol

Chemical Properties

density	1.58±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	11.37±0.40(Predicted)
color	White to light yellow
InChIKey	BZKIOORWZAXIBA-UHFFFAOYSA-N
SMILES	CN1N=CC(C2=CC=C3C(NN=C(CN)C3=C2)=O)=C1C1C(=C(Cl)C=C(OC2CC2)C=1C#N)F

Hazard Information

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Chengdu DingDang Pharmaceutical Co., Ltd.

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Dalian Meilun Biotech Co., Ltd.

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

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Nantong Hi-Future Biotechnology Co., Ltd

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Bide Pharmatech Ltd.

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Changzhou Borl Biotechnology Co.,LTD

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TargetMol Chemicals Inc.

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Shanghai Tachizaki Biomedical Research Center

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Websitehttp://www.chemlab-tachizaki.com/

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Model	Route	Dose (mg/kg)	Cl_total (mL/min/kg)	V_dss (L/kg)	t_1/2 (h)
CD-1 mouse.	i.v.	3	83	6.3	1.5
Beagle dog	i.v.	2	14	3.4	4.8
Cynomolgus monkey	i.v.	2	15	2.3	6.1

Model	Route	Dose (mg/kg)	C_max (ug/mL)	AUC_inf (h*ug/mL)	F (%)
CD-1 mouse.	p.o.	30	1.16	4.85	80
Beagle dog	p.o.	10	1.40	7.47	59
Cynomolgus monkey	p.o.	10	/	/	41

Animal Model:	Lu-99 (an MTAP/CDKN2A-deleted human lung cancer cell line ) xenograft tumor models^[2]
Dosage:	12.5, 25, 50, and 100 mg/kg/d, 21 day
Administration:	Oral gavage
Result:	Reduced the tumor volume with 86% tumor growth inhibition (TGI) at 50 mg/kg and 88% TGI at 100 mg/kg.

2630904-45-7

Chemical Properties

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Biological Activity

in vivo

IC 50

storage

References

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