2624336-88-3

Lenalidomide 4'-PEG2-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG2-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1].

Lenalidomide 4'-PEG2-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG2 linker with terminal amine ready for conjugation to a target protein ligand.

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[1] Wang S, et al. Monofunctional intermediates for ligand-dependent target protein degradation. China, WO2017176958A1. 2017-10-12.