26097-80-3

Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle. It inhibits polymerization of microtubules isolated from bovine brain with an IC₅₀ value of 64.2 μM. Formulations containing cambendazol have been used to treat strongyloidiasis in humans and have been studied as potential chemotherapeutics.

Anthelmintic.

Camdan (Merck);.

Store at -20°C

[1] GROVE D I. Strongyloides ratti and S. stercoralis: the effects of thiabendazole, mebendazole, and cambendazole in infected mice.[J]. The American journal of tropical medicine and hygiene, 1982: 469-476. DOI: 10.4269/ajtmh.1982.31.469
[2] PAUL A. FRIEDMAN  Edward G P. Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin[J]. Biochimica et biophysica acta. General subjects, 1978, 544 3: Pages 605-614. DOI: 10.1016/0304-4165(78)90334-3
[3] S A BICALHO  Q P  O J Le?o. Cambendazole in the treatment of human strongyloidiasis.[J]. American Journal of Tropical Medicine and Hygiene, 1983, 32 5: 1181-1183. DOI: 10.4269/ajtmh.1983.32.1181
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