GW409544 is a potent PPARα and PPARγ activator, with EC50 values of 2.3 nM and 0.28 nM for PPARα and PPARγ, respectively. GW409544 can be used for the research of metabolic and cardiovascular diseases[1].
Definition
ChEBI:GW 409544 is a monocarboxylic acid.
IC 50
PPARα: 2.3 nM (EC50); PPAR-γ: 0.28 nM (EC50)
References
[1] Xu HE, et al. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13919-24. DOI:10.1073/pnas.241410198
