2566497-96-7

Name	Antitumor agent-68
CAS	2566497-96-7
Molecular Formula	C17H11NO2
Molecular Weight	261.27
MOL File	2566497-96-7.mol

Synonyms

Antitumor agent-68 2-Propynoic acid, 3-phenyl-, 1H-indol-5-yl ester

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Chemical Properties

Boiling point	465.3±27.0 °C(Predicted)
density	1.30±0.1 g/cm3(Predicted)
pka	16.05±0.30(Predicted)

Hazard Information

Uses

Antitumor agent-68 is a potent tubulin inhibitor. Antitumor agent-68 shows potent anticancer activity with IC50s of 3.6 and 3.8 μM for HeLa and MCF-7 cells, respectively. Antitumor agent-68 exhibits good scavenging activity of ROS and DPPH radical in a dose-dependent manner[1]. Antitumor agent-68 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1] Domenico Iacopetta, et al. Synthesis, anticancer and antioxidant properties of new indole and pyranoindole derivatives. Bioorg Chem.?2020 Dec;105:104440. DOI:10.1016/j.bioorg.2020.104440

Supplier

Shanghai Beckham Medical Technology Co., Ltd

Telephone 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Telephone 15317229551

Websitehttps://www.ureiko.com

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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