2563873-76-5

Amino-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

NH₂-PEG24-COOH (Amino-PEG24-acid, CAS 2563873-76-5) is a linear, monodisperse polyethylene glycol (PEG) derivative. This compound possesses a primary amine group and a terminal carboxyl group, and exhibits excellent water solubility and biocompatibility. It can be used as a highly water-soluble cross-linker or spacer in biocoupling, drug delivery, and targeted therapies such as PROTACs and antibody-drug conjugates (ADCs).

Amino-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

PEGs

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562