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Fluprostenol isopropyl ester is a potent F-series prostaglandin receptor agonist that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma.^1,2 13,14-epoxy Fluprostenol isopropyl ester is an impurity generated in the production of fluprostenol isopropyl ester. This product is a 4:96 diastereomeric mixture of epoxides.

13,14-epoxy Travoprost (13,14-epoxy Fluprostenol isopropyl ester) is a mixture of diastereomeric epoxides generated during production of Travoprost (HY-B0584). Travoprost is a selective agonist for prostaglandin F receptor, which exhibits an ocular hypotensive efficacy[1].

1. Sorbera, L.A., and Casta?er, J. Travoprost Drugs Future 25(1),41-45(2000).
2. Hellberg, M.R., Sallee, V.L., McLaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist J. Ocul. Pharmacol. Ther. 17(5),421-432(2001).