253435-07-3

α-Viniferin has anti-oxidant and anticancer activities. ?-Viniferin and vincristine can enhance the anti-tumor effects efficiently by inducing HepG2 cell apoptosis. 3. α-Viniferin strongly inhibits the activities of the two CYPs dose dependently. 4. α-Viniferin suppresses the expression of proinflammatory genes iNOS and COX-2 in the early stage of inflammation by inhibiting the Akt/PI3K-dependent NF-κB activation and inhibits the production of proinflammatory mediators NO and PGE2 in the late stage by stimulating Nrf2-mediated HO-1 signaling pathway in LPS-stimulated BV2 microglial cells.

NO | PGE | NOS | COX | NF-kB | PI3K | Akt | Nrf2 | HO-1 | P450 (e.g. CYP17)