2489390-15-8

Name	Alomfilimab
CAS	2489390-15-8

Synonyms

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Chemical Properties

form	Liquid
color	Colorless to light yellow

Hazard Information

Uses

KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response[1].

in vivo

KY-1044 (Alomfilimab; SAR 445256; 10 mg/kg; ip; twice a week for 3 weeks) mIgG2a (effector enable) monotherapy blocks tumor growth in lymphoma/myeloma tumor models^[1].
In syngeneic mouse tumor models, KY-1044 depletes ICOS^high Treg and increases the intratumoral T_Eff:Treg ratio, resulting in increased secretion of IFNγ and TNFα by T_Eff cells^[1].

Animal Model:	8- to 10-week-old wild-type female Balb/C or C57BL/6J mice with A20 cells^[1]
Dosage:	200 μg (10 mg/kg)
Administration:	IP; twice a week for 3 weeks starting from 6 days following tumor cell implantation
Result:	Triggered an antitumor response, with more than 90% of the mice being free from measurable disease at the end of the study (day 42).

References

[1] Richard C.A. Sainson, et al. An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression. Cancer Immunol Res. 2020 Dec;8(12):1568-1582. DOI:10.1158/2326-6066.CIR-20-0034

Supplier

Guangzhou Hongyuan Chemical Co.,Ltd

Telephone 15817493340

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1222417/0_EN.htm

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Wuhan Acumen Bio-Technology Co.,ltd

Telephone027-027-16602739303 16602739303

Websitehttp://www.yjybiochem.com/

Wanxin Biotechnology (Jiaxing) Co., LTD

Telephone0573-83568680 18057391398

Website

Wuhan Maixi Biotechnology Co., Ltd

Telephone18007167883 18007167883

Websitehttps://www.mabnus.cn

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