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(2S,4R)-4-Hydroxy-L-glutamic Acid is a metabolite of Glutamic acid (G596960).

ChEBI: Erythro-4-hydroxy-L-glutamic acid is a 4-hydroxy-L-glutamic acid. It has a role as a Saccharomyces cerevisiae metabolite. It is functionally related to a L-glutamic acid. It is a conjugate acid of an erythro-4-hydroxy-L-glutamate(1-).

(4R)-4-Hydroxy-L-glutamic acid or (2S,4R)-4-hydroxyglutamate was shown to activate the metabotropic glutamate receptorsmGlu1amGlu2and mGlu8a in a dose-dependent manner. ''Substrate for aminotransferase; pharmacological characterization at human glutamate transporter subtypes 1-3; for studying structure-activity relationships (SAR) for ionotropic and metabotropic glutamate receptors.