2480284-01-1

Name	4-Thiazolecarboxylic acid, 2-[[4-(aminosulfonyl)benzoyl]amino]-, cyclopropylmethyl ester
CAS	2480284-01-1
Molecular Formula	C15H15N3O5S2
Molecular Weight	381.43
MOL File	2480284-01-1.mol

Synonyms

hCAI/II-IN-4 4-Thiazolecarboxylic acid, 2-[[4-(aminosulfonyl)benzoyl]amino]-, cyclopropylmethyl ester

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Chemical Properties

density	1.543±0.06 g/cm3(Predicted)
pka	6.21±0.50(Predicted)

Hazard Information

Uses

hCAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with Ki values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. hCAI/II-IN-4 has anti-hypoxia activities and low toxicity. hCAI/II-IN-4 can be used for acute mountain sickness (AMS) research[1].

in vivo

hCAI/II-IN-4 (compound 6d) (400-2000 mg/kg; p.o.; Male BLAB/c mice of hypoxia) has no apparent toxic effect in vivo^[1].

Animal Model:	Male BLAB/c mice of hypoxia^[1]
Dosage:	400, 500 and 2000 mg/kg
Administration:	Oral administration
Result:	Prolonged the survival time of mice by 29.3% compared with that of the blank control group.

References

[1] Yang C, et al. N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II. Bioorg Chem. 2020 Jul;100:103931. DOI:10.1016/j.bioorg.2020.103931

Supplier

Shanghai Beckham Medical Technology Co., Ltd

Telephone 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

Tianjin Kailiqi Biotechnology Co., Ltd.

Telephone 15076683720

Websitehttp://www.cw-bio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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