245329-02-6

L-Phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide, is a peptide agonist of proteinase-activated receptor1,and 2 (PAR-1 and -2), and thus can be used to study PAR1,2 action in cells and in animals.

FSLLRY-NH2 is a peptide antagonist of the protease activated receptor 2 (PAR2). The peptide blocks agonist induced itching in rodent models. In cell based assaysthe peptide inhibits agonist-induced cardiocyte remodelingand production of cytokines by endothelial cells.''The ability of FSLLRY-NH2 to decrease visceral hypersensitivity (VH) suggests th at PAR2 is involved in the maintenance of VH.

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