2442597-56-8

VU6015929 (Compound 7e) is further evaluated in a rat IV (0.5 mg/kg)/PO (3 mg/kg) PK study in a 10% EtOH/40% PEG400/50% saline vehicle. VU6015929 displays a good in vitro:in vivo correlation (IVIC), with moderate in vivo clearance (CL_p = 34.2 mL/min/kg), an ~3 hour half-life, moderate volume of distribution at steady state (V_ss = 4.3 L/kg) and 12.5% oral bioavailability with a rapid T_max (0.75 hr)^[1].