2417955-18-9

Name	Benzaldehyde, 2-hydroxy-6-[[(3S)-4-[[2-(2-hydroxyethyl)-3-pyridinyl]carbonyl]-3-morpholinyl]methoxy]-
CAS	2417955-18-9
Molecular Formula	C20H22N2O6
Molecular Weight	386.4
MOL File	2417955-18-9.mol

Synonyms

Benzaldehyde, 2-hydroxy-6-[[(3S)-4-[[2-(2-hydroxyethyl)-3-pyridinyl]carbonyl]-3-morpholinyl]methoxy]-

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Chemical Properties

Boiling point	637.5±55.0 °C(Predicted)
density	1.338±0.06 g/cm3(Predicted)
form	Solid
pka	7.79±0.10(Predicted)
color	White to light yellow

Hazard Information

Description

Osivelotor is an allosteric modulator of haemoglobin S.

Uses

Osivelotor is an orally effective small molecule. Osivelotor is an allosteric regulator of deoxyhemoglobin S (HbS). Osivelotor increases the affinity of HbS to oxygen, inhibits HbS polymerization, and thus prevents erythrocyte sickling in the blood. Osivelotor can be used for research of sickle cell disease (SCD) [1] [2].

in vivo

Osivelotor (20-150 mg/kg; Oral gavage; Once a day; 21 days) significantly improves red blood cell health, reduces red blood cell sickle response and maintains oxygen delivery to peripheral tissues in a mouse model of sickle cell disease ^[2].

Animal Model:	Male knock-in Townes mice with an HbSS genotype ^[2]
Dosage:	20, 40, 75 and 150mg/kg
Administration:	Oral gavage (i.g.); once a day; 21 days
Result:	Reduced red blood cell sickling, improved red blood cell deformability and prolonged red blood cell half-life. Restored haemoglobin levels to the normal range. Improved oxygen delivery and increased tolerance to severe hypoxia.

References

[1] WHO Drug Information-World Health Organization (WHO).
[2] Dufu K, et al. GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. Br J Haematol. 2023 Jul;202(1):173-183. DOI:10.1111/bjh.18771

Supplier

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Soochow Chirally Material Science and Technology Co.,Ltd

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TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

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Website

Aikon International Limited

Telephone025-58851090 13408877820

Websitehttps://www.aikonchem.com/

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