2417674-27-0

AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC50s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer[1].

AMPK (α2): 60.7 nM (IC₅₀); AMPK (α1): 107 nM (IC₅₀); KDR: 3820 nM (IC₅₀)

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[1] Matheson CJ, et al. Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors. Eur J Med Chem. 2020 Jul 1;197:112316. DOI:10.1016/j.ejmech.2020.112316