SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand with no targeted degradation ability and can be used as a control reagent for the VHL ubiquitin ligase ligand. SJF-0661 is a variant obtained by inverting the stereocenter of the key hydroxyproline group in the VHL ligand[1].
Biological Activity
SJF 0661 is the negative control for SJF 0628 . Binds BRAF without inducing degradation.
IC 50
VHL
storage
Store at -20°C
References
[1] Alabi S, et al. Mutant-selective degradation by BRAF-targeting PROTACs. Nat Commun. 2021 Feb 10;12(1):920. DOI:10.1038/s41467-021-21159-7
