24127-59-1

96-32-2

3179-31-5

24127-59-1

3-Mercapto-1,2,4-triazole (8 g, 0.08 mol) was dissolved in tetrahydrofuran (500 ml) under stirring conditions at room temperature. Subsequently, methyl bromoacetate (16 g, 0.10 mol) was added and the reaction system was cooled to 0°C. At this temperature, triethylamine (20 ml) was slowly added dropwise. After the dropwise addition, the reaction system was heated to 60°C and stirred continuously for 1 hr. After completion of the reaction, the system was cooled to room temperature and stirring was continued for 12 hours. The complete reaction was confirmed by thin layer chromatography (TLC) monitoring. The reaction mixture was filtered and the solvent was removed by evaporation. The resulting solid was collected by filtration and drum dried at 40 °C to give the final methyl 2-((1H-1,2,4-triazol-5-yl)thio)acetate (IV-1) as a white solid in a yield of 11.3 g in 82% yield.