IACS-15414 is a potent and orally bioavailable SHP2 inhibitor with an IC50 value of 122 nM.
References
[1] Czako B, et al. Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 Oct 28;64(20):15141-15169. DOI:10.1021/acs.jmedchem.1c01132
