2411100-70-2

Name	9(10H)-Acridinone, 2-methoxy-5,6-dimethyl-
CAS	2411100-70-2
Molecular Formula	C16H15NO2
Molecular Weight	253.3
MOL File	2411100-70-2.mol

Synonyms

STING Agonist 12b 9(10H)-Acridinone, 2-methoxy-5,6-dimethyl-

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Chemical Properties

storage temp.	Store at -20°C
solubility	DMF: 1 mg/ml,DMSO: 1 mg/ml
form	A crystalline solid

Hazard Information

Biological Activity

STING agonist 12b is an agonist of stimulator of interferon genes (STING).1 It binds to STING (Kd = 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells.

References

1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)

Supplier

Changzhou Furuisi Biotechnology Co., Ltd

Telephone0519-85524369

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1441214/0.htm

ChemeGen 中国

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Websitehttps://www.chemegen.com

Beijing Biocreative Technology Co., Ltd.

Telephone 15522676233

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TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

Nanjing Tengyi Biotechnology Co., Ltd

Telephone025-58851786 17714337195

Websitehttps://tybiochem.com/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

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