Description
Tauroursodeoxycholic acid-d
4 (TUDCA-d
4) is intended for use as an internal standard for the quantification of tauroursodeoxycholic acid by GC- or LC-MS. TUDCA is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid .
1,2 TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears.
2 It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington's disease, ischemic brain injury, and retinal disorders.
3,2
References
1. Beuers, U. Effects of bile acids on hepatocellular signaling and secretion Yale J. Biol. Med. 70(4),341-346(1997).
2. Boatright, J.H., Nickerson, J.M., Moring, A.G., et al. Bile acids in treatment of ocular disease J. Ocul. Biol. Dis. Infor. 2(3),149-159(2009).
3. Vang, S., Longley, K., Steer, C.J., et al. The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases Glob. Adv. Health Med. 3(3),58-69(2014).
