Description
Tauroursodeoxycholic acid-d
4 (TUDCA-d
4) is intended for use as an internal standard for the quantification of tauroursodeoxycholic acid by GC- or LC-MS. TUDCA is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid .
1,2 TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears.
2 It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington's disease, ischemic brain injury, and retinal disorders.
3,2
Uses
Tauroursodeoxycholate-d4 (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
References
1. Beuers, U. Effects of bile acids on hepatocellular signaling and secretion Yale J. Biol. Med. 70(4),341-346(1997).
2. Boatright, J.H., Nickerson, J.M., Moring, A.G., et al. Bile acids in treatment of ocular disease J. Ocul. Biol. Dis. Infor. 2(3),149-159(2009).
3. Vang, S., Longley, K., Steer, C.J., et al. The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases Glob. Adv. Health Med. 3(3),58-69(2014).
