2409072-27-9

HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1].

HDAC6: 20.7 nM (IC₅₀); HDAC8: 7750 nM (IC₅₀)

[1] Shih-Wei Wang, et al. Synthesis and biological evaluation of 2-quinolineacrylamides. Bioorg Med Chem. 2020 Feb 1;28(3):115250. DOI:10.1016/j.bmc.2019.115250