239110-15-7

Fluopicolide is a fungicide used for the control of a range of Oomycete diseases including downy mildew and blight. It has a low aqueous solubility and is not highly volatile. It tends to be fairly persistent in most soil systems and stable in water-sediment systems. There is also a risk of it leaching to groundwater. No significant risks to human health have been identified. It is moderately toxic to most biodiversity but there is less of a risk to bees.

Fluopicolide is a useful chemical that kills oomycetes in vitro.

ChEBI: A member of the class of benzamides obtained by formal condensation of the carboxy group of 2,6-dichlorobenzoic acid with the amino group of [3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylamine. A fungicide used for the control of a range of diseases incl ding downy mildew and blight.

Fluopicolide is commercially produced through a multi-step chemical synthesis that constructs its acylpicolide structure, designed for high efficacy against oomycete pathogens. The process begins with the chlorination of benzene derivatives to form a 2,6-dichlorobenzamide core. This is then coupled via an amide bond with a substituted pyridine ring bearing a trifluoromethyl group and an additional chlorine atom. The key intermediate—3-chloro-5-(trifluoromethyl)pyridin-2-ylmethylamine—is synthesized separately and reacted with the benzoyl chloride derivative under controlled conditions to yield the final active ingredient: 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}benzamide.

Fungicide: Fluopicolide is targeted for control of oomycete fungal diseases on turf, ornamentals, and several food uses including grapes and six crop groupings (leafy vegetables, fruiting vegetables, brassica vegetables, root and tuber vegetables, bulb vegetables, and cucurbits) that may be grown throughout the U.S [83] .

INFINITO®, Bayer; PRECIDIO

Protectant, novel mode of action as fluopicolide delocalises spectrin-like proteins

Fungicide