ChemicalBook CAS DataBase List 2376580-08-2

2376580-08-2

Name	1,3-Dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one, 9-(3-fluorophenyl)-6,9-dihydro-5-(2-hydroxyethyl)-
CAS	2376580-08-2
Molecular Formula	C20H16FNO5
Molecular Weight	369.34
MOL File	2376580-08-2.mol

Chemical Properties

Boiling point	577.4±50.0 °C(Predicted)
density	1.53±0.1 g/cm3(Predicted)
form	Solid
pka	14.61±0.10(Predicted)
color	White to off-white

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Animal Model:	C57BL/6 mice implanted (s.c.) with luciferase-expressing ID8 cells^[1]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced the tumor weight by 2-fold, and is well-tolerated. Reduced the lung metastases. Inhibited YB-1 expression and downstream MDR1 (IHC assay of tumor sample).

2376580-08-2

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