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NF-κΒ activator 2 is a potent and orally active NF-?B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-?B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].

NF-κB: 1.58 μM (EC₅₀)

[1] Mathew B, et, al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-?B activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952. DOI:10.1016/j.ejmech.2020.112952