Biological Activity
FNIR-Tag, NHS is a near-infrared fluorescent dye; supplied as an NHS ester for coupling to primary amine groups. FNIR-Tag, NHS allows a higher degree of labeling (DOL) with less aggregation than leading competitor product. When conjugated to antibodies, FNIR-Tag, NHS exhibits reduced liver uptake in vivo compared with leading competitor conjugates. In addition, FNIR-Tag, NHS conjugates are significantly brighter than leading competitor conjugates at similar labeling densities in vivo and in vitro. Antibody conjugation efficiency is greatest at pH 7.4. Excitation/emission maxima = 766/788 nm; Extinction coefficient = 200,000 M-1cm-1; QY = 0.099. For further information about how FNIR-Tag, NHS may be used, please see our protocol: Conjugation Protocol for Amine Reactive Dyes.
