2357113-68-7

Name	1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-
CAS	2357113-68-7
Molecular Formula	C25H35N5O7
MDL Number	MFCD34473299
Molecular Weight	517.57
MOL File	2357113-68-7.mol

Synonyms

5-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 5-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-1-piperazinyl]-2-(2,6-dioxo-3-piperidinyl)-

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Hazard Information

Biological Activity

Thalidomide-Piperazine-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1001.

Supplier

Jilin Province Woda Biotechnology Co., Ltd.

Telephone 13504435624

Websitehttps://www.wodapro.com

Changzhou Bojia Biomedical Technology Co., Ltd.

Telephone 2122619822

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList849747/0.htm

ShenZhen Trendseen Biological Technology Co.,Ltd.

Telephone13417589054 13417589054

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList312717/0.htm

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