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Biotin-PEG7-thiourea is reactive with amine-containing macromolecule. The hydrophilic PEG arm improves water solubility. The biotin groups serve as an affinity label towards the proteins avidin and streptavidin. The thiourea group can be used as a source of sulfide, such as for converting alkyl halides to thiols.

Biotin-PEG7-thiourea is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329