Description
3β-hydroxy-7-oxo-5-Cholestenoic Acid-d
3 is intended for use as an internal standard for the quantification of 3β-hydroxy-7-oxo-5-cholestenoic acid by GC- or LC-MS. 3β-hydroxy-7-oxo-5-Cholestenoic acid is a metabolite of the oxysterol 7-keto cholesterol .
1 It is formed from 7-keto cholesterol by the cytochrome P450 (CYP) isoform CYP27A1. Plasma levels of 3β-hydroxy-7-oxo-5-cholestenoic acid are increased in a rat model of liver injury induced by carbon tetrachloride.
2
References
1. Heo, G.-Y., Bederman, I., Mast, N., et al. Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells J. Lipid Res. 52(6),1117-1127(2011).
2. Xu, S.-Y., Zhang, Y., Han, T., et al. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry-based plasma metabolomics study of hepatoprotective effect of cuscutae semen on CCl4 -induced liver injury model of rats Biomed. Chromatogr. 36(12),e5489(2022).
