23328-69-0

4-chloromorpholine is a useful reagent for selective and efficient chlorination of activated aromatics.

1. Smith, J. R. L.; McKeer, L. C.; Taylor, J. M. OSC 1993, 8, 167.
2. Smith, J. R. L.; McKeer, L. C.; Taylor, J. M. JCS(P2) 1987, 1533.

4-chloromorpholine is synthesized by Morpholine and aqueous Sodium Hypochlorite at <10 °C, followed by ether extraction, concentration below 30 °C, and vacuum distillation.^1,2