2322322-23-4

Methyltetrazine-amido-PEG5-alkyne is a heterobifunctional crosslinker. This reagent enables simple and efficient incorporation of a tetrazine moiety onto TCO-attached antibodies, peptide or other biomolecule under mild condition. The alkynes is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry. PEG5 space increase the compound's aqueous solubility.

Methyltetrazine-amido-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005