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Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III?intermediate filament protein?vimentin?(VIM), to induce hyperphosphorylation?of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability and?pharmacokinetic?profiles than FiVe1[1].

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[1] Martínez-Pe?a F, et al. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. Eur J Med Chem. 2022 Nov 15;242:114638. DOI:10.1016/j.ejmech.2022.114638