2311-91-3

Monoperoxyphthalic Acid is used as a reagent in the synthesis of 4-Hydroxyretinoic Acid (H953300); a novel substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7.

Mild peroxycarboxylic acids for effecting epoxidation of π-bonds, Baeyer-Villiger reactions, and the  oxidation of diverse heteroatoms including nitrogen, sulfur, and selenium.

Monoperoxyphthalic acid is prepared as required by the addition of phthalic  anhydride to 30% aqueous Hydrogen Peroxide,  in the presence of Sodium Hydroxide or Sodium  Carbonate.  Magnesium monoperoxyphthalate is prepared by the addition of phthalic anhydride and  Magnesium Oxide to aqueous hydrogen peroxide.
Drying: magnesium monoperoxyphthalate should be  dried over calcium chloride in a desiccator.

The Journal of Organic Chemistry, 24, p. 1354, 1959 DOI: 10.1021/jo01091a612

Magnesium monoperoxyphthalate may be stored at room temperature.  All work should be carried in an efficient fume hood behind a polycarbonate safety screen.