2306389-03-5

(S,R,S)-AHPC-C6-NH2 is a E3 ligase ligand-linker conjugate that is comprised of the (S,R,S)-AHPC based VHL ligand and a six carbon alkane linker used for EED-Targeted PROTAC.

(S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in?PROTAC?technology[1].

VHL

[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery.?Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277