2305087-92-5

Name	PDE9-IN-1
CAS	2305087-92-5
Molecular Formula	C17H23FN6O2
MDL Number	MFCD32062828
Molecular Weight	362.4
MOL File	2305087-92-5.mol

Synonyms

PDE9-IN-1 PDE-9-IN-1,PDE9IN1,PDE9 IN 1 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1-cyclopentyl-6-[[(1R)-2-[(3S)-3-fluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]-1,5-dihydro-

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Chemical Properties

Boiling point	596.2±60.0 °C(Predicted)
density	1.58±0.1 g/cm3(Predicted)
form	Solid
pka	1.00±0.20(Predicted)
color	White to off-white

Hazard Information

Uses

PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC50 of 8.7 nM[1].

in vivo

PDE9-IN-1 (2.5 and 5.0 mg/kg; Oral administration; daily for 21 days) effectively recovers learning and memory function^[1].

Animal Model:	Unilateral common carotid artery occlusion (UCCAO) mouse model^[1]
Dosage:	2.5 and 5.0 mg/kg
Administration:	Oral administration; daily for 21 days
Result:	Significantly reduced the day 6 escape latency time and increased the frequency of platform area crossings, and recovered learning and memory function. High dose group possibly improved the escape latency time of mice.

IC 50

PDE9A: 8.7 nM (IC₅₀)

References

[1] Wu Y, et al. Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. J Med Chem. 2019 Apr 25;62(8):4218-4224. DOI:10.1021/acs.jmedchem.8b01041

Spectrum Detail

PDE9-IN-1(2305087-92-5)¹HNMR

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

Guangzhou Ruidi Biotechnology Co., Ltd.

Telephone020-82099279 18988941402

Websitehttp://www.ubiochem.com/

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