227951-89-5

Name	FK-788
CAS	227951-89-5
Molecular Formula	C26H25NO6
MDL Number	MFCD32204701
Molecular Weight	447.48
MOL File	227951-89-5.mol

Synonyms

FK-788 Acetic acid, 2-[[(6R)-6-[[[(diphenylamino)carbonyl]oxy]methyl]-5,6,7,8-tetrahydro-6-hydroxy-1-naphthalenyl]oxy]-

show less show more

Chemical Properties

Boiling point	667.3±55.0 °C(Predicted)
density	1.328±0.06 g/cm3(Predicted)
pka	3.19±0.10(Predicted)

Hazard Information

Uses

FK-788 is a PGI(2) and IP agonist with a strong anti-aggregation effect, with an IC50 of 18 nM and a high binding affinity for the human recombinant IP receptor, with a Ki value of 20 nM[1][2].

References

[1] Kouji Hattori, et al. Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3091-5. DOI:10.1016/j.bmcl.2005.04.047
[2] Fujiko Takamura, et al. Metabolism investigation leading to novel drug design 2: orally active prostacyclin mimetics. Part 5. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4475-8. DOI:10.1016/j.bmcl.2006.06.033

Supplier

Amadis Chemical Company Limited

Telephone571-89925085

Websitehttp://www.amadischem.com

Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy