ChemicalBook CAS DataBase List 2274802-95-6

2274802-95-6

Name	Methanesulfonamide, N-[(2S,3S)-1-(2-hydroxy-2-methyl-1-oxopropyl)-2-[(2,3',5'-trifluoro[1,1'-biphenyl]-3-yl)methyl]-3-pyrrolidinyl]-
CAS	2274802-95-6
Molecular Formula	C22H25F3N2O4S
Molecular Weight	470.51
MOL File	2274802-95-6.mol

Chemical Properties

Boiling point	605.5±65.0 °C(Predicted)
density	1.39±0.1 g/cm3(Predicted)
solubility	Acetonitrile: Slightly Soluble: 0.1-1 mg/mL DMSO: Sparingly Soluble: 1-10 mg/mL
form	Solid
pka	9.62±0.40(Predicted)
color	White to off-white

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Animal Model:	Orexin/ataxin-3 mice model^[1]
Dosage:	3 and 10 mg/kg
Administration:	Oral administration (p.o.); single dose
Result:	Significantly increased total wakefulness time. Decreased total NREM sleep time and REM sleep time. Significantly ameliorated fragmentation of wakefulness with fewer number of wakefulness episodes and longer mean duration of wakefulness episodes. Significantly increased gamma power during wakefulness at dose of 10 mg/kg.