ChemicalBook CAS DataBase List 2260886-64-2

2260886-64-2

Name	JND3229
CAS	2260886-64-2
Molecular Formula	C33H41ClN8O2
MDL Number	MFCD32644591
Molecular Weight	617.18
MOL File	2260886-64-2.mol

Chemical Properties

density	1.34±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO : 12.5 mg/mL (20.25 mM; Need ultrasonic)
form	Solid
pka	16.01±0.40(Predicted)
color	White to light yellow

Hazard Information

Spectrum Detail

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Wuhan Kaymke Chemical Co., Ltd.,

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Shanghai Lollane Biological Technology Co.,Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Rechem science Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Beijing Jin Ming Biotechnology Co., Ltd.

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Chuzhou KeMail Chemical Technology Co., Ltd

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ROSEWA HOLDING GROUP CO.,LIMITED

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Zhejiang J&C Biological Technology Co.,Limited

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Wuhan ChemNorm Biotech Co.,Ltd.

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Shanghai Dongyang Biotechnology Co., Ltd.

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Changzhou Chenhong Biotechnology Co., Ltd.

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Wuxi Donghe Pharmaceutical Technology Co., Ltd.

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Websitehttp://www.cegchemical.com

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Wuhan ChemNorm co., LTD.

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Energy Chemical

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cjbscvictory

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Animal Model:	BALB/c mice (bearing established BaF3-EGFR19D/T790M/C797S mouse xenograft tumors model)^[1].
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; twice daily for 10 days.
Result:	Caused an obvious suppression of tumor growth with a Tumor Growth Inhibition (TGI) value of 42.2%. Showed well tolerance without obvious body weight loss or other obvious toxic sign in the treated animals. Significantly decreased the level of phosphorylated EGFR (p-EGFR) tin the tumor tissues.

2260886-64-2

Chemical Properties

Hazard Information

Uses

in vivo

storage

References

Spectrum Detail

Supplier