225641-84-9

201054-55-9

225641-84-9

General procedure for the synthesis of tert-butyl ((1R,3S)-3-hydroxycyclopentyl)carbamate from (1S,4R)-4-cyclopenten-1-ol-2-amino-tert-butyloxycarbonyl: Tert-butyl (1S,4R)-4-hydroxycyclopent-2-enylcarbamate (2.0 g, 10 mmol) was dissolved in methanol (20 mL), and the reaction flask was subjected to three times nitrogen Displacement. 10% Pd/C catalyst (0.2 g, 10%, w/w) was added to the above solution, followed by three displacements with hydrogen. The reaction mixture was stirred at room temperature and hydrogen atmosphere (1 atm) for 14 hours. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration. The filtrate was concentrated to afford the target product ((1R,3S)-3-hydroxycyclopentyl)carbamic acid tert-butyl ester (1.9 g, yield: 95%).