2247491-97-8

IUN91978, also known as NPB, is a specific inhibitor of the phosphorylation of human BCL-2-associated death promoter (hBAD) specifically on Ser99, thereby exerting its effect independently of AKT and other kinase activities despite the demonstration of AKT-mediated BAD-Ser99 phosphorylation. NPB was reported by Pandey V et al in PNAS. 2018, 115(44):E10505-E10514. This product has no formal name at the moment.

NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC50 of 0.41 μM[1].

[1] Pandey V, et al. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10505-E10514. DOI:10.1073/pnas.1804897115