2245942-72-5

SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].

HDAC6: 12 nM (IC₅₀); HDAC8: 1.23 μM (IC₅₀); HDAC1: 1.39 μM (IC₅₀); HDAC11: 5.12 μM (IC₅₀); HDAC5: 6.91 μM (IC₅₀); HDAC7: 8.34 μM (IC₅₀)

Store at -20°C,unstable in solution, ready to use.

[1] Shen S, et al. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 4. DOI:10.1021/acs.jmedchem.9b00946