2243-05-2

5α-Androstan-3,6,17-trione is an analog of 4-androstene-3,6,17-trione (4-AT, 6-OXO), an irreversible aromatase inhibitor that is used to increase serum androgen levels. 5α-Androstan-3,6,17-trione is considered a designer drug and is regulated in the United States. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

(5α)-Androstane-3,6,17-trione is identified as biotransformation products of testosterone. Also, it is an aromatase inhibitor in human placental microsomes.

[1] MITSUTERU NUMAZAWA  Ayako M  Masachika Tsuji. Studies on aromatase inhibition with 4-androstene-3,6,17-trione: Its 3β-reduction and time-dependent irreversible binding to aromatase with human placental microsomes[J]. Journal of steroid biochemistry, 1987, 28 3: Pages 337-344. DOI: 10.1016/0022-4731(87)91028-4
[2] DAN ROHLE. Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males.[J]. Journal of the International Society of Sports Nutrition, 2007, 4: 13. DOI: 10.1186/1550-2783-4-13