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DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1]. DMA-135 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

DMA-135 is a cell penetrant and potent inhibitor of human enterovirus 71 (EV71) translation and replication th at targets the IRES domain of EV71. DMA-135 binds allosterically to EV71 SLII RNA and stabilizes ternary complex consisting of AUF1-SLII-DMA-135. Alsoprevious data indicate th at DMA-135 exhibit comparable affinity to HIV-1-TAR and HIV-2-TAR.

[1] Davila-Calderon J, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11(1):4775. Published 2020 Sep 22. DOI:10.1038/s41467-020-18594-3