22244-14-0

Direct Black 38 free acid is an azo dye. Direct Black 38 induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1].

[1] Beije B. Induction of unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats exposed in vivo to the benzidine-derived azo dye, Direct Black 38. Mutat Res. 1987 Apr;187(4):227-34. DOI:10.1016/0165-1218(87)90041-3
[2] Byrne SL, et al. Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo. PLoS One. 2013 Jul 23;8(7):e70199. DOI:10.1371/journal.pone.0070199