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CAS DataBase List
2222280-83-1
2222280-83-1
Name
SHP504
CAS
2222280-83-1
Molecular Formula
C23H15ClN4O4
Molecular Weight
446.84
MOL File
2222280-83-1.mol
Synonyms
SHP504
3-[4-(2-Chlorobenzyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-4-hydroxybenzoic Acid
Benzoic acid, 3-[4-[(2-chlorophenyl)methyl]-4,5-dihydro-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-4-hydroxy-
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Chemical Properties
Boiling point
796.2±70.0 °C(Predicted)
density
1.54±0.1 g/cm3(Predicted)
pka
4.12±0.10(Predicted)
Hazard Information
Uses
SHP504 is a SHP2 phosphatase inhibitor, with an IC50 of 21 μM for SHP21–525[1].
References
[1] Michelle Fodor, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem Biol. 2018 Mar 16;13(3):647-656. DOI:
10.1021/acschembio.7b00980
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https://www.targetmol.cn/
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