222035-13-4

The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G₂-M transition during the cell cycle. Cdk2 Inhibitor II is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC₅₀ = 60 nM). It is cell permeable, reversible, and ATP-competitive.

CDK2 inhibitor II, is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2.