PF-06815189 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.4 nM[1].
IC 50
PDE2A: 0.4 nM (IC50)
References
[1] Stepan AF, et al. Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189. ACS Med Chem Lett. 2018 Jan 4;9(2):68-72. DOI:10.1021/acsmedchemlett.7b00343