ChemicalBook CAS DataBase List 22128-62-7

22128-62-7

Name	Chloromethyl chloroformate
CAS	22128-62-7
EINECS(EC#)	244-793-3
Molecular Formula	C2H2Cl2O2
MDL Number	MFCD00077688
Molecular Weight	128.94
MOL File	22128-62-7.mol

Chemical Properties

Melting point	<-20°C
Boiling point	107-108 °C(lit.)
density	1.449 g/mL at 20 °C
refractive index	n20/D 1.428
Fp	95°C
storage temp.	2-8°C
solubility	Chloroform (Soluble), Methanol (Slightly)
form	clear liquid
color	Colorless to Light yellow to Light orange
Water Solubility	Slightly miscible with water.
Sensitive	Moisture Sensitive
BRN	506426
Stability:	Extremely Moisture Sensitive, Hygroscopic
InChI	1S/C2H2Cl2O2/c3-1-6-2(4)5/h1H2
InChIKey	JYWJULGYGOLCGW-UHFFFAOYSA-N
SMILES	ClCOC(Cl)=O
CAS DataBase Reference	22128-62-7(CAS DataBase Reference)
EPA Substance Registry System	22128-62-7(EPA Substance)

Safety Data

Symbol(GHS)	GHS05,GHS06
Signal word	Danger
Hazard statements	H314-H331
Precautionary statements	P261-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes	T
Risk Statements	R23:Toxic by inhalation. R34:Causes burns. less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . less more
RIDADR	UN 2745 6.1/PG 2
WGK Germany	3
F	10-19-21
HS Code	2915.90.5050
HazardClass	6.1
PackingGroup	II
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 3 Inhalation Skin Corr. 1B

Hazard Information

General Description

A colorless liquid with a penetrating, irritating odor. Denser than water. Contact may irritate skin, eyes and mucous membranes. Toxic by ingestion, inhalation and skin absorption. Used to make other chemicals.

Reactivity Profile

CHLOROMETHYLCHLOROFORMATE is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Air & Water Reactions

Reacts with moisture in air to generate heat and hydrochloric acid fumes [Merck, 11th ed., 1989]. Reacts with water.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Vapors may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Chemical Properties

Chloromethyl chloroformate is Clear Colourless Oil

Uses

Chloromethyl chloroformate is used as a reagent in the synthesis of carbamates and carbonates.

Uses

Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 1808, 1984 DOI: 10.1021/ja00318a042

Material Safety Data Sheet(MSDS)

Well-known Reagent Company Product Information

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