22128-43-4

Moderately toxic by ingestion. A moderateeye irritant.

4-METHYLOCTIN-4-OL (also known as 4-Methyl-1-octyn-4-ol) serves as a pharmaceutical intermediate in the preparation of Misoprostol. Misoprostol is a synthetic prostaglandin drug used for the prevention and treatment of gastric and duodenal ulcers, induction of labour, and termination of pregnancy.

In a 50 L glass reactor, 2.2 kg (91.6 mol) of metallic magnesium and 20 L of anhydrous tetrahydrofuran were added, and a reaction was initiated by stirring of about 3.21 kg 3-bromopropyne (26.9111001). After the reaction was initiated, the system became black, A mixture of 7.51 kg of 2-hexanone (75 mol), 7.5 kg of 3-bromopropyne (63 mol) and 20 ml of anhydrous tetrahydrofenosine was added dropwise at 25-35 ° C, and the reaction mixture was added dropwise (2-hexanone , Organic phase merger, dry, concentrated crude. The product was purified by distillation under reduced pressure to give 7.5 kg of pure 4-Methyloctin-4-ol with a purity of 97.1% and a yield of 71.4%