2212020-52-3

Orforglipron (0.94-4.8 nM in plasma concentration, i.v., or 0.05-0.1 mg/mL, i.g. for 5 days) suppresses food intake in a dose-dependent manner, promotes insulin secretion and decreases blood glucose in cynomolgus monkey model^[1].
Orforglipron (0.05-1.35 mg/kg, i.g.) reaches C_max 2 hours after administration at all doses, exhibits proportional ratio of increase in plasma drug exposure to dose increase, indicates a dose-dependent absorption in the gastrointestinal tract^[1].

Pharmacokinetic Analysis of Orforglipron in cynomolgus monkey ^[1]