apicularen B
2,4-Heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-7-[[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]oxy]-3,4,5,6,7,8,9,10-octahydro-14-hydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1-propen-1-yl]-, (2Z,4Z)-
Apicularen B is a V-ATPase inhibitor and cytotoxic macrolide that can be obtained from the myxobacterium Archangium gephyra. Apicularen B can be used in the study of V-ATPase-related diseases, such as osteopetrosis[1][2].
References
[1] K?teles I, et al. Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants. Molecules. 2020 Sep 2;25(17):4009. DOI:10.3390/molecules25174009 [2] Hong J, et al. Inhibition of vacuolar-type (H+)-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells. FEBS Lett. 2006 May 15;580(11):2723-30. DOI:10.1016/j.febslet.2006.04.031
